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At MADA Clinic and Spa we always strive to provide our clients with the latest and best regenerative aesthetic treatments.
This month we would like to introduce one of the recent active ingredient used in aesthetic medicine. Polydeoxyribonucleotide known as PDRN is a naturally-occurring building block in your DNA that helps to repair damaged skin cells and stimulate collagen production.
Regenerative medicine has witnessed remarkable advancements in recent years, with Polydeoxyribonucleotide (PDRN) emerging as a groundbreaking therapeutic agent. This bioactive compound, extracted from the DNA of salmon trout or chum salmon, has shown significant potential in promoting tissue repair and regeneration.
What is PDRN?
It is primarily derived from the sperm of salmon, which is known for their high genetic similarity to human DNA. This similarity facilitates the effective integration and utilisation of PDRN in human tissues, promoting a range of therapeutic benefits.
Mechanism of Action
PDRN works through several mechanisms to support tissue regeneration and healing:
Stimulation of Cell Proliferation: PDRN promotes the proliferation of fibroblasts, which are crucial for wound healing and tissue repair. By stimulating these cells, PDRN enhances the body's natural repair processes.
Anti-Inflammatory Properties: PDRN has been shown to reduce inflammation by inhibiting the production of pro-inflammatory cytokines. This property makes it beneficial in treating conditions characterised by chronic inflammation.
Angiogenesis Promotion: PDRN aids in the formation of new blood vessels, a process known as angiogenesis. This is particularly important in tissue regeneration, as new blood vessels supply essential nutrients and oxygen to healing tissues.
Activation of Adenosine A2A Receptors: By activating these receptors, PDRN helps in reducing inflammation and promoting tissue repair. This receptor pathway is crucial for its regenerative effects.
In dermatology, PDRN is used for its anti-aging and skin rejuvenation properties. It helps in:
reducing wrinkles
improving skin elasticity
promoting overall skin health By stimulating collagen production and enhancing skin cell turnover, PDRN provides a non-invasive alternative to more aggressive cosmetic procedures.
As a result, PDRN repair and regeneration treatments have 2 primary effects:
Healing Effect:
Encourage intense skin repair
Reduce the appearance of acne scars and stretch marks
Minimises pores
Anti-ageing effect:
Reduce wrinkles, fine lines, & pore size
Boost cell renewal & new cell growth
Stimulate collagen production
Improve skin elasticity and hydration
The future of PDRN in regenerative medicine looks incredibly promising. Ongoing research continues to uncover new applications and refine existing treatments. With advancements in biotechnology, we can expect more efficient and targeted delivery systems for PDRN, enhancing its therapeutic potential further.
Moreover, as the understanding of PDRN's mechanisms deepens, there is potential for developing combination therapies that leverage its regenerative properties alongside other treatment modalities. This could revolutionize the way we approach complex medical conditions, offering more effective and holistic treatment options.
At MADA Clinic and Spa our Clinical director developed special treatment protocol that can be personalised for ultimate results to maximize the improvement of his or her skin.