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🔬 What Are Polynucleotides in Aesthetics?
- MADA Clinic and Spa
- Aug 21
- 2 min read
Polynucleotides (PNs) are highly purified DNA fragments, usually derived from salmon or trout, used as injectable skin boosters. Unlike dermal fillers (which add volume), polynucleotides act as bio-regenerators — they stimulate your own cells to repair and rejuvenate.
They’re sometimes called biostimulators or skin revitalisers.
🌟 Benefits for Skin
Polynucleotides help by:
Boosting collagen & elastin → firmer, plumper skin
Improving hydration → healthy, dewy glow
Strengthening skin barrier → more resilient skin
Smoothing fine lines & wrinkles
Reducing pigmentation & scarring
Refreshing under-eye area → improving dark circles & crepiness
Supporting wound healing (used medically for burns & ulcers)
🩺 How They’re Used in Skin Treatments
Micro-injections
Tiny blebs injected into the dermis (like Profhilo or mesotherapy)
Common areas: face, under-eyes, neck, décolletage, hands
Combination Treatments
Microneedling + PDRN → channels help deliver it deeper
PRP + PDRN → regenerative “power duo”
LED light therapy + PDRN → boosts healing & collagen effects
Treatment Protocol
Usually 2–3 sessions spaced 2–4 weeks apart
Results last 6–9 months before maintenance is needed
💉 Downtime & Side Effects
Mild redness, swelling, or tiny bumps (“mosquito bite” look) at injection sites
Usually settles within 24–72 hours
Low risk because the product is biocompatible
✅ Best For
Early to moderate skin aging
Crepey under-eye skin / dark circles
Dry, dull, or uneven skin
Scarring (acne, surgical)
People wanting regeneration without filler volume
⚠️ Avoid if pregnant, breastfeeding, have severe fish allergies, or skin infection at injection site.
✨ In short: Polynucleotides are like a reset button for your skin — repairing at a cellular level instead of just masking issues.
