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🔬 What Are Polynucleotides in Aesthetics?
- MADA Clinic and Spa
- Aug 21, 2025
- 2 min read
Polynucleotides (PNs) are highly purified DNA fragments, usually derived from salmon or trout, used as injectable skin boosters. Unlike dermal fillers (which add volume), polynucleotides act as bio-regenerators — they stimulate your own cells to repair and rejuvenate.
They’re sometimes called biostimulators or skin revitalisers.
🌟 Benefits for Skin
Polynucleotides help by:
Boosting collagen & elastin → firmer, plumper skin
Improving hydration → healthy, dewy glow
Strengthening skin barrier → more resilient skin
Smoothing fine lines & wrinkles
Reducing pigmentation & scarring
Refreshing under-eye area → improving dark circles & crepiness
Supporting wound healing (used medically for burns & ulcers)
🩺 How They’re Used in Skin Treatments
Micro-injections
Tiny blebs injected into the dermis (like Profhilo or mesotherapy)
Common areas: face, under-eyes, neck, décolletage, hands
Combination Treatments
Microneedling + PDRN → channels help deliver it deeper
PRP + PDRN → regenerative “power duo”
LED light therapy + PDRN → boosts healing & collagen effects
Treatment Protocol
Usually 2–3 sessions spaced 2–4 weeks apart
Results last 6–9 months before maintenance is needed
đź’‰ Downtime & Side Effects
Mild redness, swelling, or tiny bumps (“mosquito bite” look) at injection sites
Usually settles within 24–72 hours
Low risk because the product is biocompatible
âś… Best For
Early to moderate skin aging
Crepey under-eye skin / dark circles
Dry, dull, or uneven skin
Scarring (acne, surgical)
People wanting regeneration without filler volume
⚠️ Avoid if pregnant, breastfeeding, have severe fish allergies, or skin infection at injection site.
✨ In short: Polynucleotides are like a reset button for your skin — repairing at a cellular level instead of just masking issues.
