The Ultimate Guide to Types of Microneedling: Nano, Medical, and RF Microneedling
- MADA Clinic and Spa
- Mar 14
- 4 min read

Microneedling has emerged as one of the most popular skincare treatments for rejuvenation, tackling various skin concerns like fine lines, acne scars, and uneven texture. But did you know there are multiple types of microneedling techniques available, each tailored to specific skin needs? This blog explores three primary types: Nano Microneedling, Medical (Standard) Microneedling, and RF (Radiofrequency) Microneedling. We'll also dive into how these treatments can be supercharged with PDRN and exosomes for even better results.
1. Nano Microneedling
Nano microneedling is a gentle, non-invasive treatment that uses silicone or polymer tips instead of traditional needles. These nano-needles create microscopic channels in the skin’s outermost layer, allowing skincare products to penetrate more effectively without causing any pain or downtime.
Best For:
Sensitive skin
Fine lines and wrinkles
Mild texture issues
Early signs of aging
Advantages:
Completely painless
No downtime
Suitable for all skin types
2. Medical (Standard) Microneedling
Medical microneedling, also known as collagen induction therapy (CIT), uses fine needles to create controlled micro-injuries in the skin. This process stimulates the natural production of collagen and elastin, making it highly effective for treating more pronounced skin issues. Additionally, it can be combined with electroporation—a technique that uses electrical pulses to enhance the delivery of active ingredients deep into the skin—for even greater effectiveness in boosting collagen production, brightening and skin repair.

Best For:
Acne scars
Stretch marks
Deep wrinkles
Uneven skin tone and texture
Advantages:
Perfect for aging prevention
Stimulates deep skin regeneration
Improves long-term skin firmness
Can be customized for different depths
3. RF (Radiofrequency) Microneedling
RF microneedling takes standard microneedling to the next level by incorporating radiofrequency energy. The needles deliver RF waves deep into the skin, stimulating collagen production while tightening the tissue. This dual-action approach makes it ideal for more advanced skin concerns.

Best For:
Skin laxity
Deep wrinkles
Advanced acne scars
Enlarged pores
Advantages:
Tightens and lifts the skin
Long-lasting results
Addresses deeper skin issues
Enhancing Microneedling with PDRN and Exosomes
Combining microneedling with advanced skincare technologies like PDRN and exosomes is a game-changer in skin rejuvenation.
The Role of PDRN in Microneedling
PDRN (Polydeoxyribonucleotide) is a DNA-based substance derived from salmon sperm. It has remarkable regenerative and healing properties due to its ability to stimulate cell growth and tissue repair. When used in conjunction with microneedling, PDRN can enhance the skin’s natural healing process by promoting faster recovery, reducing inflammation, and boosting collagen production. Here's how PDRN benefits the microneedling procedure:
Accelerates Healing: PDRN has been shown to speed up the healing process by stimulating tissue regeneration at the cellular level. This means less downtime after treatment and quicker results.
Boosts Collagen Production: Collagen is a protein that provides structure and elasticity to the skin. PDRN promotes the production of collagen and elastin, making the skin look firmer, plumper, and more youthful.
Reduces Inflammation: One of the key benefits of PDRN is its anti-inflammatory effect. It helps calm the skin, reducing redness and swelling that can occur post-microneedling.
Improves Skin Texture and Tone: PDRN not only accelerates healing but also helps refine the skin's texture, making it smoother and more even.
Exosomes: A Game-Changer for Skin Regeneration
Exosomes are extracellular vesicles that play a crucial role in cell-to-cell communication. They contain a variety of bioactive molecules, including proteins, lipids, and RNA, which are responsible for promoting healing, tissue regeneration, and inflammation reduction. Exosomes are derived from stem cells and have become one of the most innovative tools in regenerative medicine. Here's why they are a perfect match for microneedling:
Regenerative Properties: Exosomes contain growth factors and other bioactive molecules that promote tissue regeneration. When applied to the skin after microneedling, they help accelerate collagen production and improve skin healing.
Enhanced Skin Repair: Exosomes promote skin repair by enhancing the activity of fibroblasts and other skin cells responsible for producing collagen and elastin. This results in smoother, firmer, and more youthful-looking skin.
Anti-Aging Benefits: Exosomes help repair damaged skin at a cellular level, making them an effective treatment for fine lines, wrinkles, and other signs of aging. By stimulating the regeneration of skin cells, exosomes help restore a youthful glow.
Improved Skin Hydration: Exosomes support the skin's natural moisture barrier, helping to lock in hydration and reduce dryness. This leads to smoother and more radiant skin after treatment.

The combination of microneedling with PDRN and exosomes creates a synergistic effect that can drastically improve the results of your skin rejuvenation treatment:
Amplified Regeneration: Both PDRN and exosomes enhance collagen production and tissue regeneration, but when used together, they offer a powerful boost to the skin’s natural healing processes. Microneedling creates the perfect environment for these substances to penetrate deeply into the skin, maximizing their effectiveness.
Reduced Downtime: While microneedling typically requires a few days of recovery, the addition of PDRN and exosomes can accelerate healing, reducing redness, swelling, and discomfort. Patients often report faster recovery times and improved results.
Long-Lasting Results: The regenerative properties of both PDRN and exosomes mean that the results of the treatment last longer. Patients can enjoy smoother, firmer, and more youthful skin for months after the procedure. It helps to maximize collagen and elastin production.
Customizable Treatments: Because microneedling is highly customizable, the addition of PDRN and exosomes allows practitioners to tailor treatments to meet individual skin needs, whether it's for acne scars, hyperpigmentation, fine lines, enhancing hydration or overall skin rejuvenation.
Which Microneedling Treatment is Right for You?
Choosing the right type of microneedling depends on your skin’s unique needs and goals. For those looking for a gentle boost, nano microneedling is perfect. If you're dealing with more significant concerns like acne scars or wrinkles, medical or RF microneedling may be the better option.
To further elevate your results, consider combining your microneedling session with serums like PDRN or exosomes. These advanced treatments can take your skincare journey to the next level, delivering radiant, youthful skin.

Are you ready to experience the transformative power of microneedling? Schedule a consultation today to determine the best option for your skin!